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Bypass modules

Bypass module - online dialysis sampling

The bypass module serves as an alternative for sampling when the dialysis probe is ruled out for technical reasons, for example due to a lack of free ports on the bioreactor or a lack of internal space.

The bypass module is particularly suitable for online sampling in perfusion cell cultures. Installation is always outside the bioreactor and the medium to be measured is pumped through the module.

The bypass module stainless steel consists of three blocks which can be easily fixed and sealed by allen screws. The front block and the middle block are forming the donor-channel, which connects the flowing stream of reactor medium with the dialysis membrane. The rear block serves as the acceptor-channel and fixes the dialysis membrane with the middle block. The dialysis membrane creates a sterile barrier between the two channels and permits diffusion of the analyte into the acceptor stream. Two barbed tubing adapters for tubing I.D. up to 6 mm or I.D. 9 mm are used for the connection with the donor stream and UNF analytical fittings are used for the connection of the analyser manifold.
The bypass module stainless steel is used for larger volume flow rates of the donor stream.

 

The bypass module PEEK consists of two blocks which can be easily fixed and sealed by allen screws. The front block is forming the donor-channel, which connects the flowing stream of reactor medium with the dialysis membrane. The rear block serves as the acceptor-channel and fixes the dialysis membrane with the front block. The dialysis membrane creates a sterile barrier between the two channels and permits diffusion of the analyte into the acceptor stream. The bypass module PEEK is prepared with two pump tubing adapters for tubing I.D. 2 mm and two o-rings for the additional sealing of the adapter.
The bypass module PEEK is used for smaller volume flow rates of the donor stream.

As an alternative for single-use bioreactors, a single-use dialysis sampling module is available.

Features

  • Sampling system for the online analyser TRACE C2 Control and MultiTRACE
  • Sterile online dialysis sampling
  • Installation outside of the bioreactor
  • Sterilisation in an autoclave

Advantages

  • Alternative to the dialysis probe
  • Online sampling in connection with an external pump for cell cultures
  • Robust dialysis membrane
  • Independent of the fermenter size
  • Can be used for fermentation processes with steam sterilisation
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